{"id":6518,"date":"2024-07-25T10:43:11","date_gmt":"2024-07-25T08:43:11","guid":{"rendered":"https:\/\/healthmag.al\/?p=6518"},"modified":"2024-07-25T10:43:11","modified_gmt":"2024-07-25T08:43:11","slug":"e-kapi-kanceri-nga-merzia-si-ndikon-stresi-dhe-gjendja-emocionale-ne-semundjet-kanceroze","status":"publish","type":"post","link":"https:\/\/healthmag.al\/index.php\/2024\/07\/25\/e-kapi-kanceri-nga-merzia-si-ndikon-stresi-dhe-gjendja-emocionale-ne-semundjet-kanceroze\/","title":{"rendered":"\u201cE kapi kanceri nga merzia\u201d- Si ndikon stresi dhe gjendja emocionale ne semundjet kanceroze?"},"content":{"rendered":"

Dr. Emiljana HUTI shprehet ne HealthMag PODCAST<\/a> se: Stresi dobeson sistemin tone imunitar duke e bere te paafte te eliminoje qelizat jo normale ne organizem, te cilat duke u riprodhuar ne ritme me te rritura, kthehen ne qeliza kancerogjene.<\/p>\n

 <\/p>\n

\u201cE zuri kanceri nga merzia\u201d Si ndikon stresi dhe gjendja emocionale ne semundjet kanceroze?<\/strong><\/p>\n

Ekziston nj\u00eb nd\u00ebrgjegj\u00ebsim n\u00eb rritje se stresi psikologjik po njihet gjithnj\u00eb e m\u00eb shum\u00eb si nj\u00eb faktor rreziku n\u00eb fillimin dhe p\u00ebrparimin e kancerit. Stresi mund t\u00eb jet\u00eb akut ose kronik. Koncepti i stresit q\u00eb diskutohet ne kete artikull p\u00ebrkufizohet si stresi kronik i lidhur me alternimet n\u00eb boshtin hipotalamo-hipofiz\u00eb- glandule adrenale (HPA), aktivizimin e sistemit nervor simpatik (SNS) dhe p\u00ebrshtatje t\u00eb tjera fiziologjike si sekretimi i hormoneve te stresit.<\/p>\n

Duke p\u00ebrdorur metoda meta-analitike, Yoichi Chida dhe koleget e tij raportuan se faktor\u00ebt psikosocial\u00eb t\u00eb lidhur me stresin ishin t\u00eb lidhur me incidenc\u00ebn m\u00eb t\u00eb lart\u00eb t\u00eb kancerit n\u00eb popullata t\u00eb sh\u00ebndetshme bazuar n\u00eb rezultatet e 165 studimeve. P\u00ebr m\u00eb tep\u00ebr, duket se diagnoza e kancerit dhe ndjekja e trajtimit afatgjat\u00eb perkeqesojne \u00a0stresin te pacientet. P\u00ebrve\u00e7 k\u00ebsaj, stresi dhe ndryshimet fiziologjike t\u00eb shkaktuara prej tij mund t\u00eb modulojn\u00eb funksionin imunitar. Fijet nervore simpatike inervojn\u00eb indet limfoide imune periferike duke p\u00ebrfshir\u00eb timusin, shpretk\u00ebn, nyjet limfatike dhe palc\u00ebn e kockave, e cila siguron nj\u00eb rrug\u00eb t\u00eb drejtp\u00ebrdrejt\u00eb p\u00ebr t\u00eb rregulluar proceset imune periferike. P\u00ebr m\u00eb tep\u00ebr, p\u00ebrgjigjet imune mund t\u00eb modifikohen n\u00eb t\u00eb gjitha aspektet. K\u00ebto v\u00ebzhgime paraprake sugjerojn\u00eb implikimin e mundsh\u00ebm t\u00eb stresit kronik n\u00eb nxitjen e nj\u00eb disrregullimi imunitar dhe ndikimin e sjelljeve t\u00eb kancerit. Nj\u00eb seri studimesh raportuan se stresi kronik ndryshoi p\u00ebrb\u00ebrjen imune t\u00eb tumorit primar dhe shpretk\u00ebs, gj\u00eb q\u00eb kontribuoi n\u00eb zhvillimin e tumorit dhe avancimin e tij.<\/p>\n

Stresi kronik vepron n\u00eb sistemin imunitar p\u00ebr t\u00eb nxitur tumorogjenez\u00ebn<\/p>\n

Nocioni se nj\u00eb efekt i nd\u00ebrmjet\u00ebsuar nga stresi n\u00eb sistemin imunitar mund t\u00eb rris\u00eb ndjeshm\u00ebrin\u00eb e bujt\u00ebsit ndaj kancerit \u00ebsht\u00eb raportuar n\u00eb shum\u00eb studime. Lidhja midis stresit, sistemit imunitar dhe tumorogjenez\u00ebs perceptohet n\u00eb nj\u00eb far\u00eb mase, por deri n\u00eb \u00e7far\u00eb mase ndikon disrregullimi imunitar i nd\u00ebrmjet\u00ebsuar nga stresi n\u00eb tumorogjenez\u00ebn?<\/p>\n

    \n
  1. D\u00ebmtimi i ADN-s\u00eb<\/li>\n<\/ol>\n

    D\u00ebmtimi i ADN-s\u00eb dhe paq\u00ebndrueshm\u00ebria gjenomike jan\u00eb parakushte p\u00ebr kancerogjenez\u00eb. Nj\u00eb sistem efikas dhe i mjaftuesh\u00ebm i riparimit t\u00eb ADN-s\u00eb mbron organizmin nga rreziku i kancerit.<\/p>\n

    Stresi kronik shkakton disrregullim t\u00eb sistemit imunitar, duke \u00e7uar n\u00eb nj\u00eb gjendje pro-inflamatore si n\u00eb sistemin nervor qendror (CNS) ashtu edhe n\u00eb periferi. Citokinat e tep\u00ebrta pro-inflamatore nxisin tumorogjenez\u00ebn duke nxitur d\u00ebmtimin e ADN-s\u00eb ose duke penguar riparimin e ADN-s\u00eb p\u00ebrmes gjenerimit t\u00eb specieve reaktive t\u00eb oksigjenit (ROS) ose d\u00ebmtimit t\u00eb enzim\u00ebs s\u00eb riparimit t\u00eb ADN-s\u00eb.<\/p>\n

      \n
    1. Tumoret e lidhura me virusin<\/li>\n<\/ol>\n

      Tumoret e lidhura me virusin jan\u00eb m\u00eb t\u00eb prekur nga stresi kronik. \u00cbsht\u00eb raportuar nj\u00eb lidhje e drejtp\u00ebrdrejt\u00eb midis stresit, citotoksicitetit t\u00eb dob\u00ebsuar t\u00eb qelizave dhe tumoreve t\u00eb lidhura me papillomaviruset njer\u00ebzore (HPVs). N\u00eb m\u00ebnyr\u00eb t\u00eb ngjashme, rritja e shprehjes s\u00eb virusit latent Epstein-Barr (EBV) dhe nj\u00eb ulje e reduktuar e limfociteve T citotoksike (CTL) jan\u00eb par\u00eb n\u00eb ngjarjet stresuese. \u00cbsht\u00eb e arsyeshme t\u00eb besohet se stresi kronik dob\u00ebson imunitetin qelizor dhe nxit fillimin e tumoreve t\u00eb lidhura me virusin.<\/p>\n

       <\/p>\n

       <\/p>\n

        \n
      1. Mosfunksionimi i barrier\u00ebs s\u00eb zorr\u00ebve dhe tumorogjeneza e lidhur me kolitin<\/li>\n<\/ol>\n

        Stresi kronik \u00ebsht\u00eb raportuar t\u00eb nxis\u00eb mosfunksionim obstruktiv n\u00eb ileum dhe zorr\u00eb t\u00eb trash\u00eb dhe t\u00eb inicoj\u00eb inflamacion t\u00eb mukoz\u00ebs, gjat\u00eb t\u00eb cilit rritet p\u00ebrshkueshm\u00ebria makromolekulare dhe mukusi pakesohet ndjeshem.<\/p>\n

        Stresi kronik vepron n\u00eb sistemin imunitar p\u00ebr t\u00eb nxitur metastaz\u00ebn e tumorit<\/p>\n

        Kaskada metastatike p\u00ebrb\u00ebhet nga nj\u00eb num\u00ebr ngjarjesh sekuenciale q\u00eb p\u00ebrfshijn\u00eb shk\u00ebputjen e qelizave nga tumori primar, invadimin n\u00eb indin p\u00ebrreth, migrimin intravazues, ekstravazimin n\u00eb indet e larg\u00ebta dhe formimin e metastazave. Rezultati i metastaz\u00ebs varet nga nd\u00ebrveprimet midis qelizave kancerogjene dhe nj\u00eb mikromjedisi t\u00eb caktuar.<\/p>\n

        Stresi kronik vepron n\u00eb sistemin imunitar p\u00ebr t\u00eb d\u00ebmtuar terapin\u00eb antitumorale<\/p>\n

        P\u00ebrgjigjet imune anti-tumorale jan\u00eb t\u00eb domosdoshme edhe n\u00eb imunoterapi, kimioterapi dhe rrezatim. \u00c7do trajtim i kancerit q\u00eb merr efekt duke forcuar sistemin imunitar do t\u00eb ndikohet nga rregullimi neuroimun. Studiuesit kan\u00eb kryer studime t\u00eb thella n\u00eb nj\u00eb p\u00ebrpjekje p\u00ebr t\u00eb sqaruar mekanizmat themelor\u00eb, duke synuar t\u00eb rrisin efikasitetin e trajtimeve dhe t\u00eb p\u00ebrfitojn\u00eb pacient\u00ebt me kancer. P\u00ebrgjigjet terapeutike ndaj kimioterapis\u00eb imunogjene dhe \u00a0vaksinimit profilaktik t\u00eb tumorit ndikohen nga stresi kronik.<\/p>\n","protected":false},"excerpt":{"rendered":"

        Dr. Emiljana HUTI shprehet ne HealthMag PODCAST se: Stresi dobeson sistemin tone imunitar duke e bere te paafte te eliminoje qelizat jo normale ne organizem, te cilat duke u riprodhuar ne ritme me te rritura, kthehen ne qeliza kancerogjene.   \u201cE zuri kanceri nga merzia\u201d Si ndikon stresi dhe gjendja emocionale ne semundjet kanceroze? Ekziston […]<\/p>\n","protected":false},"author":4,"featured_media":6519,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":{"0":"post-6518","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health"},"yoast_head":"\n\u201cE kapi kanceri nga merzia\u201d- Si ndikon stresi dhe gjendja emocionale ne semundjet kanceroze? - Health Mag<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/healthmag.al\/index.php\/2024\/07\/25\/e-kapi-kanceri-nga-merzia-si-ndikon-stresi-dhe-gjendja-emocionale-ne-semundjet-kanceroze\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cE kapi kanceri nga merzia\u201d- Si ndikon stresi dhe gjendja emocionale ne semundjet kanceroze? - Health Mag\" \/>\n<meta property=\"og:description\" content=\"Dr. Emiljana HUTI shprehet ne HealthMag PODCAST se: Stresi dobeson sistemin tone imunitar duke e bere te paafte te eliminoje qelizat jo normale ne organizem, te cilat duke u riprodhuar ne ritme me te rritura, kthehen ne qeliza kancerogjene.   \u201cE zuri kanceri nga merzia\u201d Si ndikon stresi dhe gjendja emocionale ne semundjet kanceroze? 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